Faculty Bio

David Markwardt

Herbert L. and Margaret Wright DuPont Associate Professor in the Department of Biological Sciences; Associate Dean of OWU Connection; Pre-Health Advisor; Pre-Medicine/Pre-Dental Program Director

Education

• B.S., Ph.D., University of Wisconsin-Madison
• NIH Postdoctoral Fellowship (Genetics), University of Wisconsin-Madison

About

David Markwardt serves as the lead advisor for students interested in the health professions. In addition, he is the advisor for the Biomedical Engineering track within the Zoology Department and a member of the Honors Board. Markwardt likes to travel with his wife, Rachel, and kids, Anna and Henry. In addition, he is a big fan of Wisconsin sports teams and an avid reader.

Areas of Interest / Expertise

• Cell and molecular biology
• Molecular biotechnology
• Genomics

In my lab, we are working to identify genes that may play a role in the formation and maintenance of the cell wall in the fungus Saccharomyces cerevisiae, with an eye toward the development of more effective anti-fungal drugs. In particular, we are focused on better understanding the signal transduction pathways the cell uses to up- or down-regulate gene expression in response to changing environmental conditions. We use a wide variety of fundamental molecular and cellular tools and techniques, including: PCR, reverse-transcription (RT)-PCR, real-time (quantitative)-PCR, gene sequencing, bioinformatics, microbiological cell culture, DNA/RNA/protein analysis, gene cloning, electron & fluorescence microscopy, and microarray analysis.

Publications / Presentations

• Laabs, T.L.*, Markwardt, D.D.*, Slattery, M.G., Newcomb, L.L., Stillman, D.J., and Heideman, W. (2003) ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 100:10275–10280. *T.L.L. and D.D.M. contributed equally to this work.
• Hall, D.D., Markwardt, D.D., Parviz, F., and Heideman, W. (1998) Regulation of the Cln3-Cdc28 kinase by cAMP in Saccharomyces cerevisiae. EMBO J., 17(15); 4370–4378.
• Parviz, F., Hall, D.D., Markwardt, D.D., and Heideman, W. (1998) Transcriptional regulation of CLN3 expression by glucose in Saccharomyces cerevisiae. J. Bacteriol., 180(17); 4508–4515.

*Indicates an undergraduate author.

Click here to view Dr. Markwardt's curriculum vitae

Winner of the 2012 Sherwood Dodge Shankland Award for Encouragement of Teachers